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Literature summary for 2.7.11.22 extracted from

  • Shimotohno, A.; Umeda-Hara, C.; Bisova, K.; Uchimiya, H.; Umeda, M.
    The plant-specific kinase CDKF;1 is involved in activating phosphorylation of cyclin-dependent kinase-activating kinases in Arabidopsis (2004), Plant Cell, 16, 2954-2966.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information CDKF,1 is activated by phosphorylation at the activation T-loop by CDK-activating kinases, CAKs Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged CDK2 in Escherichia coli BL21(DE3) Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
K33R site-directed mutagenesis of CDK2, mutant is a substrate of the CAK1At complex and of the smaller CAK2At complex, overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
protoplast
-
 Arabidopsis thaliana
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 resolution of CAK-CDK complexes by gel filtration, overview Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana the plant-specific kinase CDKF,1 is involved in activating phosphorylation of CDK-activating kinases in Arabidopsis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CDKF,1 is activated by phosphorylation at the activation T-loop by CDK-activating kinases, CAK2At-CAK4At, while CAK1At is a subunit of a protein complex of 130 kD, which phosphorylates the T-loop of CAK2At and CAK4At and activates the CTD-kinase activity of CAK4At in vitro and in root protoplasts, CAK2At activates CDKD,3 and CAK4At activates CDKD,2, both interact with cyclin H Arabidopsis thaliana

Source Tissue

Source Tissue Comment Organism Textmining
root
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the plant-specific kinase CDKF,1 is involved in activating phosphorylation of CDK-activating kinases in Arabidopsis Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
CDK2
-
 Arabidopsis thaliana
CDKF,1
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana
cyclin H interacts with CDKF,1, dependent on, CDK activity requires specific cyclin partners Arabidopsis thaliana